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KMID : 1130320070500050493
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Korean Journal of Pediatrics
2007 Volume.50 No. 5 p.493 ~ p.496
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A Case of dapsone syndrome
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Won Yoo-Jong
Yu Seung-Taek
Kim Ok-Lan
Yoon Young-Wook
Choi Du-Young
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Abstract
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Diamino-diphenyl-sulfone (Dapsone) is widely used in the treatment of leprosy and a variety of blistering skin diseases. It sometimes has adverse side effects with common usual doses, such as skin, nervous system, gastrointestinal tract, liver, kidney and hematologic toxicity. One of these side effects is a rare but serious hypersensitivity reaction called dapsone syndrome, which occurs several weeks after the initial administration of the drug and results in unpredictable, sometimes fatal outcomes. This report deals with a 13-year-old girl’s case with typical features of dapsone syndrome that included fever, exfoliative dermatitis, jaundice, hemolytic anemia and pleural effusion after being treated with dapsone for four weeks.
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KEYWORD
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dapsone syndrome, Hemolytic anemia
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